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Reporting of transactions in Orphazyme’s shares made by persons discharging managerial responsibilities

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Reporting of transactions in Orphazyme’s shares made by persons discharging managerial responsibilities

March 25, 2021 at 3:49 PM EDT

Orphazyme A/S
Company announcement                                                                                       

No. 11/2021                                                                                                           
Company Registration No. 32266355


Copenhagen, Denmark, March 25, 2021 – Pursuant to the Market Abuse Regulation article 19, Orphazyme A/S, CVR no. 32266355 (“Orphazyme”), hereby notifies receipt of information of the following transactions in Orphazyme’s shares by persons discharging managerial responsibilities in Orphazyme:

Details of the Reporting Person / Closely Associated Person
a) Name
Catherine Moukheibir
Reason for the notification
a) Position/status
Member of the Board of Directors
b) Initial notification/Amendment
Initial notification
Details of the Company, emission allowance market participant, auction platform, auctioneer or auction monitor
a) Name
Orphazyme A/S
b) LEI code
54930025OZD2GGSQ7L42
Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a) Description of the financial instrument, type of instrument and identification code
Shares
ISIN DK0060910917
b) Nature of the transaction
Exercise of Restricted Share Units
c) Price(s) and volume(s)

Price(s) Volume(s)
 DKK61.18951,927

d) Aggregated information
Aggregated volume: 1,927 shares
Aggregated price: DKK 117,912.17
Price per share (volume weighted average): DKK 61.1895
e) Date of the transaction
March 24, 2021
f) Place of the transaction
Outside a trading venue

Details of the Reporting Person / Closely Associated Person
a) Name
Martijn Kleijwegt
Reason for the notification
a) Position/status
Member of the Board of Directors
b) Initial notification/Amendment
Initial notification
Details of the Company, emission allowance market participant, auction platform, auctioneer or auction monitor
a) Name
Orphazyme A/S
b) LEI code
54930025OZD2GGSQ7L42
Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a) Description of the financial instrument, type of instrument and identification code
Shares
ISIN DK0060910917
b) Nature of the transaction
Exercise of Restricted Share Units
c) Price(s) and volume(s)

Price(s) Volume(s)
 DKK61.18951,927

d) Aggregated information
Aggregated volume: 1,927 shares
Aggregated price: DKK 117,912.17
Price per share (volume weighted average): DKK 61.1895
e) Date of the transaction
March 24, 2021
f) Place of the transaction
Outside a trading venue

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a) Description of the financial instrument, type of instrument and identification code
Shares
ISIN DK0060910917
b) Nature of the transaction
Sale of shares to LSP V Cöoperatieve U.A.
c) Price(s) and volume(s)

Price(s) Volume(s)
 EUR-1,927

d) Aggregated information
Aggregated volume: 1,927 shares
Aggregated price: EUR 1
Price per share (volume weighted average): EUR -
e) Date of the transaction
March 24, 2021
f) Place of the transaction
Outside a trading venue

Details of the Reporting Person / Closely Associated Person
a) Name
LSP V Cöoperatieve U.A.
Reason for the notification
a) Position/status
Closely Associated Person to Martijn Kleijwegt, member of the Board of Directors
b) Initial notification/Amendment
Initial notification
Details of the Company, emission allowance market participant, auction platform, auctioneer or auction monitor
a) Name
Orphazyme A/S
b) LEI code
54930025OZD2GGSQ7L42
Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a) Description of the financial instrument, type of instrument and identification code
Shares
ISIN DK0060910917
b) Nature of the transaction
Purchase of shares from Martijn Kleijwegt
c) Price(s) and volume(s)

Price(s) Volume(s)
EUR-1,927

d) Aggregated information
Aggregated volume: 1,927 shares
Aggregated price: EUR 1
Price per share (volume weighted average): EUR -
e) Date of the transaction
March 24, 2021
f) Place of the transaction
Outside a trading venue


For additional information, please contact

Orphazyme A/S

Anders Vadsholt, Interim CEO & CFO             +45 28 98 90 55


About Orphazyme A/S 
Orphazyme is a late-stage biopharmaceutical company pioneering the Heat Shock Protein response for the treatment of neurodegenerative orphan diseases. The company is harnessing amplification of Heat Shock Proteins (or HSPs) in order to develop and commercialize novel therapeutics for diseases caused by protein misfolding, protein aggregation, and lysosomal dysfunction, including lysosomal storage diseases and neuromuscular degenerative diseases. Arimoclomol, the company’s lead candidate, is in clinical development for four orphan diseases: Niemann-Pick disease type C (NPC), Amyotrophic Lateral Sclerosis (ALS), Inclusion Body Myositis (IBM) and Gaucher disease. Orphazyme is headquartered in Denmark and has operations in the U.S. and Switzerland. Orphazyme’s shares are listed on Nasdaq U.S. (ORPH) and Nasdaq Copenhagen (ORPHA). 

About arimoclomol 
Arimoclomol is an investigational drug candidate that amplifies the production of Heat Shock Proteins (HSPs). HSPs can rescue defective misfolded proteins, clear protein aggregates, and improve the function of lysosomes. Arimoclomol is administered orally and has now been studied in seven phase 1, four phase 2 and one pivotal phase 2/3 trial. Arimoclomol is in clinical development for NPC, Gaucher Disease, IBM, and ALS. Arimoclomol has received orphan drug designation (ODD) for NPC, IBM, and ALS in the US and EU. Arimoclomol has received fast-track designation (FTD) from the U.S. Food and Drug Administration (FDA) for NPC, IBM and ALS. In addition, arimoclomol has received breakthrough therapy designation (BTD) and rare-pediatric disease designation (RPDD) from the FDA for NPC.

Forward-looking statement 
This company announcement may contain certain forward-looking statements, including in respect of the anticipated commercialization of arimoclomol. Although the Company believes its expectations are based on reasonable assumptions, all statements other than statements of historical fact included in this company announcement about future events are subject to (i) change without notice and (ii) factors beyond the Company’s control. These statements may include, without limitation, any statements preceded by, followed by, or including words such as “target,” “believe,” “expect,” “aim,” “intend,” “may,” “anticipate,” “estimate,” “plan,” “project,” “will,” “can have,” “likely,” “should,” “would,” “could”, and other words and terms of similar meaning or the negative thereof. Forward-looking statements are subject to inherent risks and uncertainties beyond the Company’s control that could cause the Company’s actual results, performance, or achievements to be materially different from the expected results, performance, or achievements expressed or implied by such forward-looking statements, including the risk that applicable regulatory authorities fail to approve arimoclomol on the anticipated timeline or at all. Except as required by law, the Company assumes no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future.

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